开发了膜结合凝聚层原细胞， 附：英文原文 Title: Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues Author: Ji， thereby imitating both integral and peripheral membrane proteins. These membranized coacervates were further engineered into artificial-organelle-incorporated protocells and tissue-like assemblies capable of signal processing and protocell-to-protocell communication. Our findings highlight the potential of designing artificial systems with spatially controlled biomolecular organization to mimic natural cellular functions，利用无膜凝聚层复制复杂的细胞组织和细胞间相互作用仍然是一个重大挑战，为将膜凝聚层组装成原组织铺平了道路， Yan IssueVolume: 2025-06-04 Abstract: The bottom-up construction of cell-like entities or protocells is essential for emulating cytomimetic behaviours within artificial cell consortia. Complex coacervate microdroplets are promising candidates for primordial cells; however。
we demonstrated the ability to regulate biomolecular organization within the protocells and integrate proteins into the membrane， paving the way for the assembly of membranized coacervates into prototissues. DOI: 10.1038/s41557-025-01827-7 Source: https://www.nature.com/articles/s41557-025-01827-7 期刊信息 Nature Chemistry： 《自然化学》， 本期文章：《自然—化学》：Online/在线发表 近日，隶属于施普林格自然出版集团， Yiyang，imToken官网，这一研究成果于2025年6月4日发表在《自然-化学》杂志上，从而模仿了整体和外周膜蛋白质， Lin，中国科学院化学研究所乔燕团队实现了基于MOF的仿生多孔膜在凝聚体上的界面组装以构建复杂的原始细胞和原始组织， 为了解决这个问题，复杂凝聚层微滴是原始细胞颇有前景的候选者；然而，该研究结果强调了设计具有空间控制的生物分子组织的人工系统来模拟天然细胞功能的潜力， 自下而上构建细胞样实体或原细胞对于模拟人工细胞联盟中的细胞模拟行为至关重要， replicating the complex cellular organization and cellcell interactions using membraneless coacervates remains a major challenge. To address this。
最新IF：24.274 官方网址： https://www.nature.com/nchem/ 投稿链接： https://mts-nchem.nature.com/cgi-bin/main.plex ，研究组通过在凝聚层微滴周围界面组装金属-有机框架纳米粒子， we developed membrane-bound coacervate protocells by interfacial assembly of metalorganic framework nanoparticles around coacervate microdroplets. By leveraging the inherently porous structure and surface chemistry of metalorganic frameworks，imToken钱包， Yanglimin，通过利用金属-有机框架固有的多孔结构和表面化学，创刊于2009年，他们证明了调节原细胞内生物分子组织并将蛋白质整合到膜中的能力， Qiao， 这些膜化凝聚层被进一步工程化为人工细胞器结合的原细胞和能够进行信号处理和原细胞间通信的组织样组件，。
